Explanation of Othera 20 mg
The acronym for Multiple-Unit Pellet System is MUPS. Nonetheless, the phrase often refers to MUPS, which has been compressed into tablets from the pharmaceutical business and research viewpoint. Hence, modified-release coated multi-particulate rollers that are then compacted to create the final tablets are called MUPS. The most modern and difficult technologies are those that provide the benefits of tablet and pellet-filled capsules in a single dose form.
- Guarantees increased bioavailability.
- Ensures that micropills are uniformly emptied from the stomach into the small intestine, which speeds up the release of the medication and dissolves the enteric coating, causing an early Tmax and Cmax.
- Assures a lower likelihood of dosage dumping.
- Combines both prolonged and quick-acting properties.
- Guarantees consistent drug release.
- Ensures reduced likelihood of localized irritation; dosed once a day.
- Guarantees more consistent and superior medication absorption.
- Reduces the esophageal time of residence more effectively than capsules.
- Reduces variation in the drug's plasma concentration.
Because of their tiny size and increased surface area, MUPS allow uniform drug absorption, leading to consistent and regulated pharmacological effects. They also provide speedy and uniform stomach emptying and consistent drug breakdown of pellets in the gastrointestinal system.
The MUPS dosage form has many more pellets than a typical pellet-filled capsule, which facilitates an additional decrease in inter- and intra-subject variation in drug absorption and clinical response. Additionally, the possibility of a dose dumped (in the stomach) and unfinished drug release is further minimized.
Indications of Othera 20 mg
Another MUPS tablet is indicated in the:
- Gastric reflux disease (GERD) is one condition for which the Othera 20 mg MUPS pill is recommended.
- Decreased risk of stomach ulcers linked to NSAID use.
- Triple treatment (eradication of H. pylori).
- Idiopathic hypersecretion with Zollinger-Ellison syndrome.
Pharmacology of Othera 20 mg
Esomeprazole reduces stomach acid by inhibiting the hydrogen-potassium adenosine triphosphatase enzyme system (the proton pump) of the gastric parietal cell. Proton pump inhibitors can effectively temporarily treat duodenal and stomach ulcers. Additionally, esomeprazole provides NSAID-associated stomach ulcer prevention and therapy.
The drug esomeprazole mainly acts on the parietal cells of the stomach, which are responsible for creating acid. It is a member of the group of medications called PPIs, or proton pump inhibitors. Its pharmacological activity focuses on blocking the proton pump, also known as hydrogen-potassium adenosine triphosphatase, an enzyme found in the parietal cells of the stomach mucosa. The last stage of the formation of stomach acid is carried out by this enzyme.
Esomeprazole efficiently reduces the stomach's production of gastric acid by binding permanently to the proton pump. This process lessens the symptoms of too much stomach acid, including acid reflux, ulcers, and heartburn.
Orally given, esomeprazole is quickly absorbed from the digestive tract and is frequently used as delayed-release capsules or tablets. One to two hours after consumption, it achieves its highest plasma concentrations. Othera 20 mg price in Bangladesh 110 tk per strip. The medicine is mostly metabolized by the cytochrome P450 system, which includes CYP2C19 and CYP3A4, in the liver. A certain amount of acid-suppressive action is retained by the primary metabolite, esomeprazole sulfone. These metabolites are subsequently excreted by the liver through urine and feces.
The medicine has long-lasting effects; one tablet can decrease acid for up to 24 hours. Esomeprazole is useful in treating a number of gastrointestinal disorders, such as peptic ulcers, erosive esophagitis, and gastroesophageal reflux disease (GERD), due to its prolonged suppression.
Esomeprazole may be metabolized differently by patients with certain CYP2C19 genetic variants, which might impact the medication's effectiveness. Drug interactions might occur if esomeprazole is used with other drugs that use the same metabolic pathways.
While headache, nausea, and stomach pain are frequent adverse effects of esomeprazole, it is often well tolerated. PPI usage that is excessive or prolonged may come with dangers, including a higher chance of infections, renal problems, and bone fractures. As a result, medical professionals frequently recommend the lowest dosage that would work for the shortest amount of time.
To summarise, esomeprazole's pharmacological action entails inhibiting the proton pump in gastric parietal cells, resulting in decreased stomach acid generation and alleviation of gastrointestinal disorders associated with acid. Because of its lengthy duration of action and efficacy in lowering acid production, it is a commonly used drug to treat a variety of digestive diseases. Patients should take esomeprazole exactly as prescribed by their doctor, and to reduce any possible dangers, consumption should be closely monitored over an extended period of time.
Composition of Othera 20 mg
Othera 20 mg Tablet: Each MUPS tablet contains 133.333 mg (15%w/w) of Othera enteric coated pellets or 20 mg of Othera (as Othera Magnesium Trihydrate USP).
Othera 20 mg Tablet: Each MUPS tablet contains 266.67 mg (15% w/w) of Othera enteric coated pellets, equal to 40 mg of Othera (as Othera Magnesium Trihydrate IJSP).
Doses of Othera 20 mg
Adult (218 years old) with erosive esophagitis:
- 40 mg once a day for 4 weeks.
- Teens and young adults (12–18 years old): 40 mg once a day for four weeks.
Maintenance of erosive esophagitis healing:
- 20 mg once daily for an adult (218 years old).
- Adolescents and children (12–18 years old): 20 mg once a day.
Risk reduction for NSAID-associated stomach ulcers:
- 20 mg once daily for 4–8 weeks in an adult (218 years old).
Elimination of H. pylori (Esomeprazole MUPS pill with 500 mg of Clarithromycin and 1000 mg of Amoxicillin):
- Adult (218 years): Take 20 mg twice daily for 7 days.
- Youngsters and teenagers (12–18): Take 20 mg daily for seven days.
Idiopathic hypersecretion and Zollinger-Ellison syndrome:
- Adult (218 years): 40–80 mg twice daily.
Children aged 1 to 11:
- Esophagitis erosive: Weight kg: 8 weeks of IO mg once a day. For 8 weeks, with a weight of 220 kg, take 10 mg or 20 mg once a day.
- To keep erosive esophagitis from healing, take 10 mg once a day.
Younger children: The Esomeprazole MUPS tablet is not recommended for use in children under one year of age.
Administration of Othera 20 mg
It is recommended to take esomeprazole MUPS pills whole, with fluids. It is not recommended to chew or crush the pills. if necessary. Mineral water is inappropriate; the pills can be dissolved in a half-glass of non-carbonated water. Othera 20 mg uses. Use of any other liquid is not advised. After 30 minutes or less, sip the liquid containing the pellets and stir until the pills dissolve. Pour a half-glass of water into the glass to rinse it, then sip. Chewing or smashing the pellets is not permitted
Interaction of Othera 20 mg
CYP2C19 and CYP3A4 widely metabolize tab. Othera 20 mg in the liver. According to research conducted in vivo and in vitro, Othera 20 is unlikely to interfere with CYPs IA2, 2A6, 2C9, 206, 2E1, and 3A4. It would be unlikely for medications metabolized through these CYP enzymes to interact in a clinically significant way. Research on drug interactions has revealed that there are no noteworthy interactions between Othera and phenytoin, warfarin, quinidine, clarithromycin, or amoxicillin.
The main enzyme that metabolizes tab Othera 20 mg, CYP2C19, may be affected by Othera. co-administration of diazepam and Othera (30 mg). Diazepam clearance was decreased by 45% due to a CYP2C19 substrate. Diazepam plasma levels have been found to be higher 12 hours after the dose and beyond. Othera prevents the release of stomach acid. Consequently, Othera may inhibit the absorption of medications (such as ketoconazole, ferrous salts, and digoxin) for which stomach pH is a significant factor in determining bioavailability.
Oral contraceptive co-administration. Quinidine, phenytoin, and diazepam do not appear to alter Othera's pharmacokinetic profile.
Clarithromycin Combination Therapy: The plasma concentrations of Othera & 14-hydroxyclarithromycin have increased when Othera, clarithromycin, & amoxicillin are administered concurrently.
Contraindications of Othera 20 mg
Patients who have a history of suspected hypersensitivity to any one of these formulations should not use esomeprazole.
Side Effect of Othera 20 mg
Constipation, dry mouth, flatulence, headache, diarrhea, nausea, and stomach discomfort are the most common side effects associated with Othera. Othera 20 mg side effects. When comparing maintenance treatment to short-term treatment, there is no discernible difference in the associated adverse events observed up to a 12-month.
Pregnancy & Lactation of Othera 20 mg
The maker suggests using care. The presence of esomeprazole and its metabolites in human breast milk is unknown. Othera 20 mg in pregnancy.
Safety Measure & Warnings of Othera 20 mg
In patients with severe hepatic failure and severe renal impairment, the Othera 20 mg medicine tablet should be administered with caution. The possibility of hip, wrist, and spine fractures may be modestly increased by using an inhibitor of the proton pump such as Othera 20 mg. especially if it is completed over a longer than one-year timeframe.
Overdose Reaction of Othera 20 mg
Any proton pump inhibitors (PPI), including esomeprazole, can cause overdoses that exacerbate pre-existing adverse effects. The amount consumed and the person's sensitivity can affect how severe the reaction is. On the other hand, a deliberate or unintentional overdose of esomeprazole may cause the following symptoms:
- Nausea & Vomiting: Overdosing on esomeprazole may result in more severe side effects such as nausea or vomiting.
- Dizziness & Headache: Excessive dosage may worsen vertigo or cause headaches that are more severe and last longer.
- Dizziness or disorientation: An overdose may cause dizziness or disorientation in extreme circumstances.
- Accelerated Heart Rate: An overdose may result in tachycardia or an accelerated heart rate.
- Abdominal Pain: Consuming too much food may cause severe or enduring cramping, pain, or abdominal discomfort.
In addition, if there are signs of discomfort or severe symptoms, or if it's unclear how much medication has been taken, medical attention should be called.
The standard course of therapy for an esomeprazole excess is supportive care to control and reduce symptoms. This might involve treating the symptoms, monitoring vital signs, and taking precautions against consequences.
To avoid accidental intake, it's crucial to keep esomeprazole & any other prescriptions out of children's reach and in a secure location. Never take more medicine than is advised without a doctor's advice, and always take prescriptions exactly as directed.
Storage Conditions of Othera 20 mg
Keep out of direct sunlight and store below 250C in a cool, dry area. Keep out of children's reach.
Generic- Esomeprazole - Othera 20 mg
One medicine that is a member of the proton pump inhibitor (PPI) drug class is esomeprazole. It is employed to treat a number of gastrointestinal disorders, most often those caused by excessive production of stomach acid. Esomeprazole is available for purchase under several brand names, the most well-known of which is Nexium.
The following are important details regarding esomeprazole:
- Method of Action: Esomeprazole prevents the stomach's gastric parietal cells from producing protonions. Lowering stomach acid production helps relieve acid reflux and heartburn, two symptoms of excess stomach acid.
- Indications: Esomeprazole is frequently administered to treat peptic ulcers, erosive esophagitis, GERD, the syndrome of Zollinger-Ellison (a rare disorder marked by excessive stomach acid production), and to avoid ulcers in patients receiving nonsteroidal anti-inflammatory medications (NSAIDs).
- Dose: Several esomeprazole dosages are available depending on the ailment being treated. It is usually used orally in the form of a solution or capsules. A healthcare professional should decide on the dosage and length of treatment. Othera 20 mg price in bd 11 tk per pc.
- Side Effects: Esomeprazole can have adverse effects, although not everybody experiences them. This is true of all medicines. Headache, nausea, diarrhea, and stomach discomfort are common adverse effects. Low magnesium levels, a higher risk for particular infections, and bone fractures are examples of uncommon but more significant adverse effects. Patients should speak with their doctor if they have any worrying side symptoms.
- Medication Interactions: Esomeprazole may have negative effects or interactions with other drugs that might reduce efficacy. It's crucial to let your doctor know about everything you take, including over-the-counter medicines and nutritional supplements. Othera 20 medicine.
- Precautions: Esomeprazole should be used with caution by pregnant or nursing women and people with specific medical disorders, such as liver illness. Before beginning the medication, it is crucial to talk to your healthcare practitioner about your medical history and any concerns you may have.
- Extended Use: PPIs, such as esomeprazole, are often used briefly to address certain ailments or manage acute symptoms. PPI overuse or prolonged usage may have specific dangers, such as an elevated risk of renal illness, infections, and bone fractures. As a result, medical professionals frequently recommend the lowest dosage that would work for the shortest amount of time.
Esomeprazole is only available with a prescription, and it's crucial that you carefully follow your doctor's directions when taking this drug. Othera 20 mg is used in Bengali. It is not intended for long-term usage without a doctor's supervision or for self-medication. See a medical expert if you have any concerns about your stomach and digestive system health for a precise diagnosis and recommended course of action.
