BIZORAN 5/40

Bizoran 5/40

5/40 MG
1 Review
AMLODIPINE 5 OLMESARTAN MEDOXOMIBIZORAN 5/40
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Description
Specification

Bizoran- Most Effective Tablet for Hypertension

Bizoran is among the two drugs that assist in managing high blood pressure are part of the drug Bizoran 5/40. Your likelihood of experiencing an attack of the heart or stroke in the future is decreased by lowering your blood pressure. You can take Bizoran 5/40 with meals or without food. It is best to take it every day at the time your doctor recommends, though.

Pharmacology of Bizoran-

Amlodipine acts as a dihydropyridine blocker of calcium channels that can stop calcium ions from entering the heart and smooth muscle of the vascular system and from passing through the blood-brain barrier. Amlodipine affects cardiomyocytes less than vascular smooth muscle cells. Amlodipine is a peripheral artery vasodilator that lowers blood pressure and peripheral vascular resistance by acting directly upon vascular smooth muscle.

The angiotensin-converting enzyme, or ACE, catalyses a process that produces angiotensin II. It is the primary vasoactive hormone associated with the renin-angiotensin system and a potent vasoconstrictor. High blood pressure is an element of pathophysiology as well. The adrenal cortex also produces aldosterone as a result of Bizoran

The vitamin D receptor, the nuclear hormone sense organ that is expressed in almost all cell types and that acts like a ligand-activated model element by binding to DNA sites to change the expression of target genes, is the mechanism through which calcitriol has biological effects. People experiencing chronic renal failure who receive calcitriol orally compensate for poor endogenous calcitriol production, which is reduced if the rate of glomerular filtration decreases below 30 ml/min.

By preventing angiotensin II from binding to the AT1 receptors in various tissues (including vascular smooth muscle and the adrenal glands), olmesartan medoxomil reduces angiotensin II vasodilatation & aldosterone release. According to in vitro binding experiments, olmesartan medoxomil acts as an adaptable competitive antagonist of the AT1 receptor. On ACE (kinase II, an enzyme that turns angiotensin I into angiotensin II and tears down bradykinin), olmesartan medoxomil had no impact.

1. Amlodipine -

Classification: Amlodipine is a member of the blockers of calcium channels (CCBs) subclass of drugs.

The Mechanisms of Effect: Amlodipine inhibits calcium channels in the cardiac cells of muscles and the outer layer of blood vessels, which is how it works. This stops calcium from reaching these cells, which causes blood arteries to relax and dilate (vasodilation). This reduces blood pressure and lessens peripheral resistance. Amlodipine helps treat illnesses like hypertension & angina because it decreases the strain on the heart.

Pharmacokinetics: Amlodipine has excellent absorption when taken orally and quickly achieves its peak plasma concentrations, according to pharmacokinetics. Because of its relatively lengthy half-life, its effects may endure for an extended time.

2. Olmesartan Medoxomil:

Classification: Angiotensin II receptor blocker (ARB) Olmesartan Medoxomil.

The mechanisms of Effect: Blood arteries are constricted by the hormone angiotensin II, which also encourages the release of aldosterone, which causes salt and water retention. Olmesartan Medoxomil prevents the effects of angiotensin II by blocking its receptor. Vasodilation (the relaxing of the blood vessels) and a decrease in blood volume are the outcomes, both of which lower blood pressure.

The mechanisms of Effect: Pharmacokinetics: Olmesartan After being administered orally, Medoxomil is quickly transformed into the drug's active ingredient ( Olmesartan ). Within hours, it achieves peak plasma concentrations. Its relatively extended duration of action makes a once-daily dosage possible.

Combination Pharmacology: Amlodipine & Olmesartan Medoxomil are combined to treat hypertension from two separate perspectives. Olmesartan Medoxomil lowers blood vessels and decreases fluid volume by preventing the actions of angiotensin II, whereas Amlodipine lowers blood vessels by restricting calcium channels. This combination can lower blood pressure more effectively than taking each medicine alone.

Clinical Use: Treatment of hypertension requiring more aggressive treatment often involves the use of the drug combination of amlodipine and olmesartan medoxomil. Remembering that everyone reacts to medicines differently is crucial, so a medical expert will choose the correct dosage and track your health.

Remember that all medications may cause adverse effects or interact with other substances. Always abide by your doctor's advice, go in for routine checkups, and let them know if you have any questions or suffer any side effects while using this combination of medications.

Doses-

Utilise individually titrated components for patients taking Bizoran. The combination mentioned above can be additionally administered with greater dosages of either Olmesartan Medoxomil or Amlodipine, depending on the situation.

For the first one to two weeks, start using 5/20 mg once a day. Then, gradually boost to a recommended dosage of 10/40 mg one time daily. The beginning dose of Amlodipine for patients 75 is 2.5 mg due to lower Amlodipine clearance in older individuals. Initial therapy using this combination medicine is not advised for people over 75 due to the combo's lowest dose of 5/20 mg

Interaction-

People on a combination of treatment and other drugs that affect RAS should have their pulse, kidney health, and electrolytes closely tracked. Nonsteroidal anti-inflammatory medications (NSAIDs) can decrease the antihypertensive properties of angiotensin II receptor antagonists (which include Olmesartan Medoxomil) (which provides selective COX2 inhibitors).

Contraindications-

Patients with diabetes cannot take Aliskiren together.

Side Effect-

The side effects are drowsiness, altered taste, swollen ankles, headache, flushing (warmth in the skin, ears, neck, and trunk), palpitations, fatigue, upset stomach, and elevated blood potassium levels. Amlodipine 5 mg & Olmesartan Medoxomil 40 mg together may be beneficial in treating hypertension, but they also carry the risk of adverse effects common to all medicines. It's crucial to remember that not everybody will experience these negative effects; some may share them more strongly than others. The following are some possible side effects of this combination:

Common Side Effects:-

Getting Dizzy: Getting dizzy is a side effect of both amlodipine & olmesartan medoxomil, particularly when getting up fast or shifting positions. This occurs as a result of their blood pressure-lowering & vasodilating characteristics.

Swelling: Peripheral edema, or swelling of both ankles and feet, can occasionally be brought on by Amlodipine.

Headache: Because these drugs reduce blood pressure, they might cause headaches.

Fewer Common Side Effects:

Fatigue: Due to the effect of the combination of blood pressure and general cardiovascular function, some people may feel weary or exhausted.

Flushing: Amlodipine may sometimes result in flushing or a feeling of warmth in the face & neck.

Palpitations: Although less frequently occurring, some people may have a rapid or unstable heartbeat.

Serious Side Effects:

Lower Blood Pressure: Although the drugs are intended to decrease blood pressure, occasionally, blood pressure can go too low, leading to symptoms including disorientation, dizziness, and fainting

Allergic Reactions: Although uncommon, allergic responses to drugs can be severe. If you have symptoms like an eruption of skin, swelling, or breathing difficulties, you should immediately get medical help.

Kidney Health: Because of the potential effect of these drugs on renal function, your doctor will probably use blood tests to check on it.

While using this combination, working closely with your healthcare practitioner is critical. To choose the best course of treatment and watch for any possible adverse effects, they will consider your past medical conditions, any other drugs you may be on, and your general state of health. Do not hesitate to contact your doctor if you encounter severe or unexpected side effects while using Amlodipine 5 mg + Olmesartan and Medoxomil 40 mg. It's also advised to monitor your blood pressure & let your doctor know if there are any significant changes.

Pregnancy & Lactation

Pregnancy class D. Amlodipine & olmesartan medoxomil shouldn't be combined since they can result in fetal mortality in the 2nd and 3rd trimesters. This combination of medications must be discontinued as soon as pregnancy is discovered. Olmesartan and Amlodipine may or may not be excreted in human milk. Given the potential risks of breastfeeding, whether to stop nursing or cease taking the medicine should be made depending on how important it is to the mother.

Safety Measure & Warnings

Due to the possibility of volume hypotension and salt depletion, it is advised to use amlodipine & olmesartan medoxomil in conjunction with caution. Individuals with extreme aortic stenosis undergo vasodilation. In individuals with significant obstructive coronary artery disease, angina or acute Ml may occur more frequently, last longer, or be more severe.

Overdose Reaction-

The first 24 hours following a Napa overdose are dangerous since they might result in pallor, nausea, vomiting, atrophy, & stomach discomfort. Damage to the liver may manifest between twelve and forty-eight hours after intake. It's possible to get metabolic acidosis and irregular glucose metabolism. In situations of severe poisoning, hepatic failure may result in encephalopathy.

Haemorrhage, hypoglycemia, brain swelling, and death. Acute renal failure with acute tubular necrosis. Even in the lack of severe liver damage, haematuria & proteinuria, which is strongly indicated by loin pain, may develop. Cardiac arrhythmias and pancreatitis have both been reported. A Napa overdose has to be treated straight soon. Therapy with charcoal activation should be considered if an excessive amount was eaten within an hour. Plasma concentrations should be measured 4 hours after eating Napa (earlier values are inaccurate).

Storage Conditions-

Keep storage below 30 ° C. Keep out of children's reach and away from sources of light.

Generic- Amlodipine 5mg+ Olmesartan Medoxomil 40 mg-

For the treatment of high blood pressure (hypertension), two separate medications—Amlodipine and Olmesartan Medoxomil—are frequently combined. Let's examine each element in detail:

1. Amlodipine (5mg): The first drug is Amlodipine (5 mg), which blocks calcium channels. Relaxing and enlarging the blood arteries enhances blood flow while lessening the strain on the heart. This aids in lowering blood pressure. Amlodipine can be taken independently or with other drugs, such as Olmesartan Medoxomil, to treat angina (chest discomfort).

2. Olmesartan Medoxomil (40mg): An ARB, or angiotensin II receptor blocker, is olmesartan medoxomil. It functions by counteracting the effects of the hormone angiotensin II, which leads the body to retain salt and water and constricts blood vessels. Olmesartan Medoxomil assists in relaxing blood vessels, decreasing blood pressure, & lessening the strain on the heart by preventing these effects. The primary purpose of this drug is to treat hypertension.

Combination Therapy-

For high blood pressure, which does not react well to one medicine alone, a mixture of amlodipine & olmesartan medoxomil is frequently used. By focusing on several pathways that contribute to increased blood pressure, this combination can offer a more all-encompassing strategy for controlling hypertension. The objective is to lower the possibility of cardiovascular problems and improve blood pressure management.

Taking drugs as directed by a healthcare expert must be crucial because they may have potential adverse effects and interactions. If your doctor has prescribed Amlodipine 5 mg plus Olmesartán Medoxomilo 40 mg, carefully follow their directions, go to your scheduled checkups, and report any unexpected symptoms or side effects you may encounter.

Conclusion-

Bizoran 5/40 price in Bangladesh is 20 taka per piece and 300 taka per strip. Each strip contains 15 pieces. The most excellent products are available from the online medical store www.care-box.com. Our products are always up to par. We are accessible round-the-clock. Customers may obtain a range of reasonably priced goods and services from Care-Box. Customers may buy cosmetics, necessary medications, and numerous daily needs locally or online and get free medical care. We supply things both regularly and urgently. Within Dhaka, regular delivery is free and takes up to two days, while expedited delivery takes just one day. Customers can utilize the above mentioned service to receive medical care after meeting with one of our on-staff doctors.

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